Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted.

Although adenovirus vectors offer many advantages, it would be desirable to develop vectors with improved expression and decreased toxicity. Toward this objective, an adenovirus vector system with deletion of both the El and E2a regions was developed. A 5.9-kb fragment of the adenovirus type 5 (Ad5)...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Zhou, H, O'Neal, W, Morral, N, Beaudet, A L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8794347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.10.7030-7038.1996
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