Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted.

Although adenovirus vectors offer many advantages, it would be desirable to develop vectors with improved expression and decreased toxicity. Toward this objective, an adenovirus vector system with deletion of both the El and E2a regions was developed. A 5.9-kb fragment of the adenovirus type 5 (Ad5)...

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Pubblicato in:	J Virol
Autori principali:	Zhou, H, O'Neal, W, Morral, N, Beaudet, A L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8794347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.10.7030-7038.1996
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