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Loss of Iron Sulfur Clusters from Biotin Synthase as a Result of Catalysis Promotes Unfolding and Degradation
Biotin synthase (BioB) is an S-adenosylmethionine radical enzyme that catalyzes addition of sulfur to dethiobiotin to form the biotin thiophane ring. In vitro, E. coli BioB is active for only one turnover, during which the [2Fe-2S](2+) cluster is destroyed, one sulfide from the cluster is incorporat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2293955/ https://ncbi.nlm.nih.gov/pubmed/18155152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.12.001 |
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