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Destruction and Reformation of an Iron-Sulfur Cluster during Catalysis by Lipoyl Synthase
Lipoyl synthase (LipA) catalyzes the last step in the biosynthesis of the lipoyl cofactor, which is the attachment of two sulfhydryl groups to C6 and C8 of a pendant octanoyl chain. The appended sulfur atoms derive from an auxiliary [4Fe–4S] cluster on the protein that is degraded during turnover, l...
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| Publicado no: | Science |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5941298/ https://ncbi.nlm.nih.gov/pubmed/29051382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan4574 |
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