A Novel ATM-Dependent Pathway Regulates Protein Phosphatase 1 in Response to DNA Damage

Protein phosphatase 1 (PP1), a major protein phosphatase important for a variety of cellular responses, is activated in response to ionizing irradiation (IR)-induced DNA damage. Here, we report that IR induces the rapid dissociation of PP1 from its regulatory subunit inhibitor-2 (I-2) and that the p...

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Bibliographic Details
Main Authors: Tang, Xi, Hui, Zhou-guang, Cui, Xiao-li, Garg, Renu, Kastan, Michael B., Xu, Bo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293124/
https://ncbi.nlm.nih.gov/pubmed/18250156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01711-07
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