The Rad50(S) allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor

Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex influences the activity of ataxia-telangiectasia mutated (ATM) in the DNA damage response. Rad50(S/S) mice...

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Detalhes bibliográficos
Main Authors: Morales, Monica, Theunissen, Jan-Willem F., Kim, Carla F. Bender, Kitagawa, Risa, Kastan, Michael B., Petrini, John H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315407/
https://ncbi.nlm.nih.gov/pubmed/16357220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1373705
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