Phosphorylation of Liver X Receptor α Selectively Regulates Target Gene Expression in Macrophages

Dysregulation of liver X receptor α (LXRα) activity has been linked to cardiovascular and metabolic diseases. Here, we show that LXRα target gene selectivity is achieved by modulation of LXRα phosphorylation. Under basal conditions, LXRα is phosphorylated at S198; phosphorylation is enhanced by LXR...

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Main Authors: Torra, Inés Pineda, Ismaili, Naima, Feig, Jonathan E., Xu, Chong-Feng, Cavasotto, Claudio, Pancratov, Raluca, Rogatsky, Inez, Neubert, Thomas A., Fisher, Edward A., Garabedian, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293109/
https://ncbi.nlm.nih.gov/pubmed/18250151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01575-07
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