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Transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

Hemochromatosis is caused by mutations in HFE, a protein that competes with transferrin (TF) for binding to the transferrin receptor (TFR1). We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis. We introduced mutations into a ubiquito...

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Autors principals: Schmidt, Paul J., Toran, Paul T., Giannetti, Anthony M., Bjorkman, Pamela J., Andrews, Nancy C.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292811/
https://ncbi.nlm.nih.gov/pubmed/18316026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.11.016
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