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Transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
Hemochromatosis is caused by mutations in HFE, a protein that competes with transferrin (TF) for binding to the transferrin receptor (TFR1). We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis. We introduced mutations into a ubiquito...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292811/ https://ncbi.nlm.nih.gov/pubmed/18316026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.11.016 |
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