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Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials

The clinical value of antimonial drugs, the mainstay therapy for leishmaniasis, is now threatened by the emergence of acquired drug resistance, and a comprehensive understanding of the underlying mechanisms is required. Using the model organism Leishmania tarentolae, we have examined the role of try...

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Bibliografski detalji
Glavni autori: Wyllie, Susan, Vickers, Tim J., Fairlamb, Alan H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292513/
https://ncbi.nlm.nih.gov/pubmed/18250189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01563-07
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