Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

The folate derivatives folic acid (FA) and folinic acid (FNA) decrease the in vivo and in vitro activities of antifolate drugs in Plasmodium falciparum. However, the effects of 5-methyl-tetrahydrofolate (5-Me-THF) and tetrahydrofolate (THF), the two dominant circulating folate forms in humans, have...

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Bibliographische Detailangaben
Hauptverfasser: Nduati, Eunice, Diriye, Abdi, Ommeh, Sheila, Mwai, Leah, Kiara, Steven, Masseno, Victor, Kokwaro, Gilbert, Nzila, Alexis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2008
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292483/
https://ncbi.nlm.nih.gov/pubmed/18259776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00436-008-0897-4
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