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Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

The folate derivatives folic acid (FA) and folinic acid (FNA) decrease the in vivo and in vitro activities of antifolate drugs in Plasmodium falciparum. However, the effects of 5-methyl-tetrahydrofolate (5-Me-THF) and tetrahydrofolate (THF), the two dominant circulating folate forms in humans, have...

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Bibliografiset tiedot
Päätekijät: Nduati, Eunice, Diriye, Abdi, Ommeh, Sheila, Mwai, Leah, Kiara, Steven, Masseno, Victor, Kokwaro, Gilbert, Nzila, Alexis
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer-Verlag 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292483/
https://ncbi.nlm.nih.gov/pubmed/18259776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00436-008-0897-4
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