Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

The folate derivatives folic acid (FA) and folinic acid (FNA) decrease the in vivo and in vitro activities of antifolate drugs in Plasmodium falciparum. However, the effects of 5-methyl-tetrahydrofolate (5-Me-THF) and tetrahydrofolate (THF), the two dominant circulating folate forms in humans, have...

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Detalhes bibliográficos
Main Authors: Nduati, Eunice, Diriye, Abdi, Ommeh, Sheila, Mwai, Leah, Kiara, Steven, Masseno, Victor, Kokwaro, Gilbert, Nzila, Alexis
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2008
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292483/
https://ncbi.nlm.nih.gov/pubmed/18259776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00436-008-0897-4
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