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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but the mechanism of its adjuvanticity remains unknown. In vitro studies showed no stimulatory effects on dendritic cells (DCs). In the absence of adjuvant, Ag was taken up by lymph node (LN)–resident DCs that acquired sol...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kool, Mirjam, Soullié, Thomas, van Nimwegen, Menno, Willart, Monique A.M., Muskens, Femke, Jung, Steffen, Hoogsteden, Henk C., Hammad, Hamida, Lambrecht, Bart N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292225/
https://ncbi.nlm.nih.gov/pubmed/18362170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071087
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