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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but the mechanism of its adjuvanticity remains unknown. In vitro studies showed no stimulatory effects on dendritic cells (DCs). In the absence of adjuvant, Ag was taken up by lymph node (LN)–resident DCs that acquired sol...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292225/ https://ncbi.nlm.nih.gov/pubmed/18362170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071087 |
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