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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but the mechanism of its adjuvanticity remains unknown. In vitro studies showed no stimulatory effects on dendritic cells (DCs). In the absence of adjuvant, Ag was taken up by lymph node (LN)–resident DCs that acquired sol...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kool, Mirjam, Soullié, Thomas, van Nimwegen, Menno, Willart, Monique A.M., Muskens, Femke, Jung, Steffen, Hoogsteden, Henk C., Hammad, Hamida, Lambrecht, Bart N.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292225/
https://ncbi.nlm.nih.gov/pubmed/18362170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071087
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