Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

Airway DCs play a crucial role in the pathogenesis of allergic asthma, and interfering with their function could constitute a novel form of therapy. The sphingosine 1–phosphate receptor agonist FTY720 is an oral immunosuppressant that retains lymphocytes in lymph nodes and spleen, thus preventing ly...

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Main Authors: Idzko, Marco, Hammad, Hamida, van Nimwegen, Menno, Kool, Mirjam, Müller, Tobias, Soullié, Thomas, Willart, Monique A.M., Hijdra, Daniëlle, Hoogsteden, Henk C., Lambrecht, Bart N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626118/
https://ncbi.nlm.nih.gov/pubmed/17080194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28295
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