Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophil...

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Detalhes bibliográficos
Main Authors: Hammad, Hamida, Plantinga, Maud, Deswarte, Kim, Pouliot, Philippe, Willart, Monique A.M., Kool, Mirjam, Muskens, Femke, Lambrecht, Bart N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947072/
https://ncbi.nlm.nih.gov/pubmed/20819925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101563
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