Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We examined the role of the interleukin (IL)-23–IL-17 and IL-12–T helper cell (Th)1 pathways in the pathogenesis of EAU. IL–23 but not IL-12 was necessary to elicit disease by immunization with the retinal antigen (Ag) in...

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Main Authors: Luger, Dror, Silver, Phyllis B., Tang, Jun, Cua, Daniel, Chen, Zoe, Iwakura, Yoichiro, Bowman, Edward P., Sgambellone, Nicole M., Chan, Chi-Chao, Caspi, Rachel R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292220/
https://ncbi.nlm.nih.gov/pubmed/18391061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071258
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