Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

Epilepsy may result from abnormal function of ion channels, such as those caused by genetic mutations. Recently, pathological alterations of the expression or localization of normal channels have been implicated in epilepsy generation, and termed ‘acquired channelopathies’. Altered expression levels...

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Autori principali: Richichi, Cristina, Brewster, Amy L., Bender, Roland A., Simeone, Timothy A., Zha, Qinqin, Yin, Hong Z., Weiss, John H., Baram, Tallie Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292123/
https://ncbi.nlm.nih.gov/pubmed/17964174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.09.003
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