Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

Epilepsy may result from abnormal function of ion channels, such as those caused by genetic mutations. Recently, pathological alterations of the expression or localization of normal channels have been implicated in epilepsy generation, and termed ‘acquired channelopathies’. Altered expression levels...

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Bibliografiske detaljer
Main Authors: Richichi, Cristina, Brewster, Amy L., Bender, Roland A., Simeone, Timothy A., Zha, Qinqin, Yin, Hong Z., Weiss, John H., Baram, Tallie Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292123/
https://ncbi.nlm.nih.gov/pubmed/17964174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.09.003
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