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Neuron-restrictive silencer factor-mediated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

OBJECTIVE: Enduring, abnormal expression and function of the ion channel hyperpolarization-activated cyclic-AMP gated channel type 1 (HCN1) occurs in temporal lobe epilepsy (TLE). We examined the underlying mechanisms, and queried if interfering with these mechanisms could modify disease course. MET...

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Detalhes bibliográficos
Main Authors: McClelland, Shawn, Flynn, Corey, Dubé, Celine, Richichi, Cristina, Zha, Qinqin, Ghestem, Antoine, Esclapez, Monique, Bernard, Christophe, Baram, Tallie Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177145/
https://ncbi.nlm.nih.gov/pubmed/21905079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22479
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