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Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments

Here, a scalable, accurate, reliable, and robust protein functional site comparison algorithm is presented. The key components of the algorithm consist of a reduced representation of the protein structure and a sequence order-independent profile–profile alignment (SOIPPA). We show that SOIPPA is abl...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Xie, Lei, Bourne, Philip E.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291117/
https://ncbi.nlm.nih.gov/pubmed/18385384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704422105
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