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A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

Functional relationships between proteins that do not share global structure similarity can be established by detecting their ligand-binding-site similarity. For a large-scale comparison, it is critical to accurately and efficiently assess the statistical significance of this similarity. Here, we re...

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Hlavní autoři: Xie, Lei, Xie, Li, Bourne, Philip E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687974/
https://ncbi.nlm.nih.gov/pubmed/19478004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp220
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