Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

Tumor cells undergo epithelial-to-mesenchymal transition (EMT) to convert from a benign to a malignant phenotype. Our recent focus has been signaling pathways that promote EMT in response to collagen. We have shown that human pancreatic cancer cells respond to collagen by up-regulating N-cadherin, w...

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Hlavní autoři: Shintani, Yasushi, Fukumoto, Yuri, Chaika, Nina, Svoboda, Robert, Wheelock, Margaret J., Johnson, Keith R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290851/
https://ncbi.nlm.nih.gov/pubmed/18362184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708137
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