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PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis
Cell adaptation to changes in oxygen (O(2)) availability is controlled by two subfamilies of O(2)-dependent enzymes: the hypoxia inducible factor (HIF)–prolyl and asparaginyl hydroxylases [prolyl hydroxylases domain (PHDs) and factor inhibiting HIF (FIH)]. These oxygen sensors regulate the activity...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290777/ https://ncbi.nlm.nih.gov/pubmed/18347341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705680105 |
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