טוען...

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-Å structure of the heparin-bridged complex

Protein C inhibitor (PCI) is a serpin with many roles in biology, including a dual role as pro- and anticoagulant in blood. The protease specificity and local function of PCI depend on its interaction with cofactors such as heparin-like glycosaminoglycans (GAGs) and thrombomodulin (TM). Both cofacto...

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Main Authors: Li, Wei, Adams, Ty E., Nangalia, Jyoti, Esmon, Charles T., Huntington, James A.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290767/
https://ncbi.nlm.nih.gov/pubmed/18362344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711055105
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