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Identification of a site involved in the block by extracellular Mg(2+) and Ba(2+) as well as permeation of K(+) in the Kir2.1 K(+) channel

The inward rectifier potassium channel Kir2.1 is more sensitive to the weakly voltage-dependent block by extracellular Mg(2+) ([Formula: see text]) than Kir2.2 and Kir2.3. We identified Glu125 in an extracellular loop before the pore region of Kir2.1 as a site responsible for this sensitivity to [Fo...

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Detalhes bibliográficos
Main Authors: Murata, Yoshimichi, Fujiwara, Yuichiro, Kubo, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290624/
https://ncbi.nlm.nih.gov/pubmed/12411513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.030650
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