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Ser165 in the Second Transmembrane Region of the Kir2.1 Channel Determines its Susceptibility to Blockade by Intracellular Mg(2+)

The strong inward rectification of Kir2.1 currents is reportedly due to blockade of the outward current by cytoplasmic magnesium (Mg(2+) (i)) and polyamines, and is known to be determined in part by three negatively charged amino acid residues: Asp172, Glu224, and Glu299 (D172, E224, E299). Our aim...

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Detalhes bibliográficos
Main Authors: Fujiwara, Yuichiro, Kubo, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229556/
https://ncbi.nlm.nih.gov/pubmed/12407079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028663
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