Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells

Insulin-secreting MIN6 cells overexpressing uncoupling protein-1 (UCP1) were studied regarding insulin secretion in response to various secretagogues. Overexpression of UCP1 prevented an increase of cytosolic ATP levels induced by glucose. In contrast, glucose utilization was not affected, nor was g...

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Detalhes bibliográficos
Main Authors: Nakazaki, Mitsuhiro, Kakei, Masafumi, Ishihara, Hisamitsu, Koriyama, Nobuyuki, Hashiguchi, Hiroshi, Aso, Katsumi, Fukudome, Michiyo, Oka, Yoshitomo, Yada, Toshihiko, Tei, Chuwa
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290263/
https://ncbi.nlm.nih.gov/pubmed/11986368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.013048
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