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The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH
P2X(2) receptor currents are potentiated by acidic pH and zinc. To identify residues necessary for proton and zinc modulation, alanines were singly substituted for each of the nine histidines in the extracellular domain of the rat P2X(2) receptor. Wild-type and mutant receptors were expressed in Xen...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290168/ https://ncbi.nlm.nih.gov/pubmed/11882669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.013244 |
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