Congenital myasthenia–related AChR δ subunit mutation interferes with intersubunit communication essential for channel gating

Congenital myasthenias (CMs) arise from defects in neuromuscular junction–associated proteins. Deciphering the molecular bases of the CMs is required for therapy and illuminates structure-function relationships in these proteins. Here, we analyze the effects of a mutation in 1 of 4 homologous subuni...

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Hlavní autoři: Shen, Xin-Ming, Fukuda, Taku, Ohno, Kinji, Sine, Steven M., Engel, Andrew G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289798/
https://ncbi.nlm.nih.gov/pubmed/18398509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34527
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