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Congenital myasthenia–related AChR δ subunit mutation interferes with intersubunit communication essential for channel gating

Congenital myasthenias (CMs) arise from defects in neuromuscular junction–associated proteins. Deciphering the molecular bases of the CMs is required for therapy and illuminates structure-function relationships in these proteins. Here, we analyze the effects of a mutation in 1 of 4 homologous subuni...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Shen, Xin-Ming, Fukuda, Taku, Ohno, Kinji, Sine, Steven M., Engel, Andrew G.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289798/
https://ncbi.nlm.nih.gov/pubmed/18398509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34527
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