Overexpression of DNA polymerase β in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

DNA polymerase β (pol β) is the most error prone of all known eukaryotic DNA polymerases tested in vitro. Here, we show that cells overexpressing pol β cDNA have acquired a spontaneous mutator phenotype. By measuring the appearance of mutational events using three independent assays, we found that g...

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Huvudupphovsmän: Canitrot, Yvan, Cazaux, Christophe, Fréchet, Mathilde, Bouayadi, Khalil, Lesca, Claire, Salles, Bernard, Hoffmann, Jean-Sébastien
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1998
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC22874/
https://ncbi.nlm.nih.gov/pubmed/9770529
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