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Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations

Prion diseases are a group of neurodegenerative disorders associated with conversion of a normal prion protein, PrP(C), into a pathogenic conformation, PrP(Sc). The PrP(Sc) is thought to promote the conversion of PrP(C). The structure and stability of PrP(C) are well characterized, whereas little is...

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Main Authors: Kuznetsov, Igor B., Rackovsky, Shalom
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287303/
https://ncbi.nlm.nih.gov/pubmed/15557265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04833404
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