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Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations
Prion diseases are a group of neurodegenerative disorders associated with conversion of a normal prion protein, PrP(C), into a pathogenic conformation, PrP(Sc). The PrP(Sc) is thought to promote the conversion of PrP(C). The structure and stability of PrP(C) are well characterized, whereas little is...
Tallennettuna:
| Päätekijät: | , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2287303/ https://ncbi.nlm.nih.gov/pubmed/15557265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04833404 |
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