Novel Analogs of D-e-MAPP and B13. Part 1. Synthesis and Evaluation as Potential Anticancer Agents

A series of novel isosteric analogs of the ceramidase inhibitors, (1S, 2R)-N-myristoylamino-phenylpropanol-1 (D-e-MAPP) and (1R, 2R)-N-myristoylamino-4′-nitro-phenylpropandiol-1, 3 (B13), with modified targeting and physicochemical properties were designed, synthesized, and evaluated as potential an...

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Hlavní autoři: Szulc, Zdzislaw M., Mayroo, Nalini, Bai, AiPing, Bielawski, Jacek, Liu, Xiang, Norris, James S., Hannun, Yusuf A., Bielawska, Alicja
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287182/
https://ncbi.nlm.nih.gov/pubmed/17869115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.08.033
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