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Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism

Mammalian capping enzymes are bifunctional proteins with both RNA 5′-triphosphatase and guanylyltransferase activities. The N-terminal 237-aa triphosphatase domain contains (I/V)HCXXGXXR(S/T)G, a sequence corresponding to the conserved active-site motif in protein tyrosine phosphatases (PTPs). Analy...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wen, Yingxia, Yue, Zhenyu, Shatkin, Aaron J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22813/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770468/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12226
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