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Identification of active site residues in mevalonate diphosphate decarboxylase: Implications for a family of phosphotransferases
A combination of sequence homology analyses of mevalonate diphosphate decarboxylase (MDD) proteins and structural information for MDD leads to the hypothesis that Asp 302 and Lys 18 are active site residues in MDD. These residues were mutated to replace acidic/basic side chains and the mutant protei...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279928/ https://ncbi.nlm.nih.gov/pubmed/15169949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04725204 |
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