Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments
Reassembly of enzymes from peptide fragments has been used as a strategy for understanding the evolution, folding, and role of individual subdomains in catalysis and regulation of activity. We demonstrate an oligomerization-assisted enzyme reassembly strategy whereby fragments are covalently linked...
Furkejuvvon:
| Publikašuvnnas: | Proc Natl Acad Sci U S A |
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| Váldodahkkit: | , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
National Academy of Sciences
1998
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12141 |
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