Structural and mechanistic studies of chloride induced activation of human pancreatic α-amylase

The mechanism of allosteric activation of α-amylase by chloride has been studied through structural and kinetic experiments focusing on the chloride-dependent N298S variant of human pancreatic α-amylase (HPA) and a chloride-independent TAKA-amylase. Kinetic analysis of the HPA variant clearly demons...

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Auteurs principaux: Maurus, Robert, Begum, Anjuman, Kuo, Hsin-Hen, Racaza, Andrew, Numao, Shin, Andersen, Carsten, Tams, Jeppe W., Vind, Jesper, Overall, Christopher M., Withers, Stephen G., Brayer, Gary D.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279296/
https://ncbi.nlm.nih.gov/pubmed/15722449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041079305
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