Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break

The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are h...

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Autors principals: Anderson, Carol M., Korkin, Dmitry, Smith, Dana L., Makovets, Svetlana, Seidel, Jeffrey J., Sali, Andrej, Blackburn, Elizabeth H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279195/
https://ncbi.nlm.nih.gov/pubmed/18334620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1646208
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