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Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat
INTRODUCTION: A pharmacokinetic (PK) model is proposed for estimation of total and free brain concentrations of fluvoxamine. MATERIALS AND METHODS: Rats with arterial and venous cannulas and a microdialysis probe in the frontal cortex received intravenous infusions of 1, 3.7 or 7.3 mg.kg(−1) of fluv...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279155/ https://ncbi.nlm.nih.gov/pubmed/17710515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9390-5 |
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