Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision

BACKGROUND -: The chronic use of opioids prior to surgery leads to lowered pain thresholds and exaggerated pain levels after these procedures. Several mechanisms have been proposed to explain this heightened sensitivity commonly termed opioid-induced hyperalgesia (OIH). Most of these proposed mechan...

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Main Authors: Liang, DeYong, Shi, Xiaoyou, Qiao, Yanli, Angst, Martin S, Yeomans, David C, Clark, J David
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279109/
https://ncbi.nlm.nih.gov/pubmed/18294378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-4-7
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