Preprotachykinin-A gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in mice

The preprotachykinin A gene (ppt-A) codes for Substance P (SP), supports nociceptive sensitization and modulates inflammatory responses after incision. Repeated opioid use produces paradoxical pain sensitization, termed opioid induced hyperalgesia (OIH) which can exacerbate pain after incision. Here...

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Main Authors: Sahbaie, Peyman, Shi, Xiaoyou, Li, Xiangqi, Liang, Deyong, Guo, Tian-Zhi, Qiao, Yanli, Yeomans, David C., Kingery, Wade S., Clark, J. David
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491068/
https://ncbi.nlm.nih.gov/pubmed/23031399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.07.009
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