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Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels

1. The structural basis for the different activation kinetics of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels was investigated with the whole-cell patch clamp technique by using HCN1, HCN4, chimeric channels and mutants in a mammalian expression system (COS-7). 2. The activatio...

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Detalhes bibliográficos
Main Authors: Ishii, Takahiro M, Takano, Makoto, Ohmori, Harunori
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278938/
https://ncbi.nlm.nih.gov/pubmed/11711564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0093k.x
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