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Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels: Evidence for an Intracellular Activation Gate

Hyperpolarization-activated cation currents (I(h)) are key determinants of repetitive electrical activity in heart and nerve cells. The bradycardic agent ZD7288 is a selective blocker of these currents. We studied the mechanism for ZD7288 blockade of cloned I(h) channels in excised inside-out patche...

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Detalhes bibliográficos
Main Authors: Shin, Ki Soon, Rothberg, Brad S., Yellen, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217248/
https://ncbi.nlm.nih.gov/pubmed/11158163
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