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Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential regulators in rhythmic activity, membrane excitability and synaptic transmission. There are four subtypes in mammals (HCN1–4); HCN4 has the slowest activation kinetics and HCN1 the fastest. Although voltage gating origi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Science Inc
2007
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075410/ https://ncbi.nlm.nih.gov/pubmed/17185333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.124297 |
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