cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca(2+)-induced Ca(2+) release in INS-1 pancreatic β-cells

1. The signal transduction pathway responsible for cAMP-dependent Ca(2+)-induced Ca(2+) release (CICR) from endoplasmic reticulum Ca(2+) stores was assessed in the insulin-secreting cell line INS-1. 2. CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked by caffeine, Sp-cAM...

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Bibliographic Details
Main Authors: Kang, Guoxin, Chepurny, Oleg G, Holz, George G
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278885/
https://ncbi.nlm.nih.gov/pubmed/11600673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0375c.xd
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