Regulation of Akt/PKB activity by P21-activated Kinase in Cardiomyocytes

Akt/PKB is a critical regulator of cardiac function and morphology, and its activity is governed by dual phosphorylation at active loop (Thr308) by phosphoinositide-dependent protein kinase-1 (PDK1) and at carboxyl-terminal hydrophobic motif (Ser473) by a putative PDK2. P21-activated kinase-1 (Pak1)...

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Bibliografiske detaljer
Main Authors: Mao, Kai, Kobayashi, Satoru, Jaffer, Zahara M., Huang, Yuan, Volden, Paul, Chernoff, Jonathan, Liang, Qiangrong
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278035/
https://ncbi.nlm.nih.gov/pubmed/18054038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2007.10.016
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