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A Phosphorylated Prodrug for the Inhibition of Pin1
Fmoc-pSer-Ψ[(Z)CH=C]-Pro-(2)-N-(3)-ethylaminoindole 1, showed moderate inhibition towards the mitotic regulator, Pin1 (IC(50) = 28.3μM). To improve the cell permeability, the charged phosphate was masked as the bis-pivaloyloxymethyl (POM) phosphate in Fmoc-(bisPOM)-pSer-Ψ[(Z)CH=C]-Pro-(2)-N-(3)-ethy...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2277516/ https://ncbi.nlm.nih.gov/pubmed/17935986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.073 |
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