Inhibition of Pin1 Reduces Glutamate-induced Perikaryal Accumulation of Phosphorylated Neurofilament-H in Neurons

Under normal conditions, the proline-directed serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in axons. In pathological conditions such as amyotrophic lateral sclerosis (ALS), motor neurons contain abnormal perikaryal accumulations of phosphorylated neur...

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Main Authors: Kesavapany, Sashi, Patel, Vyomesh, Zheng, Ya-Li, Pareek, Tej K., Bjelogrlic, Mia, Albers, Wayne, Amin, Niranjana, Jaffe, Howard, Gutkind, J. Silvio, Strong, Michael J., Grant, Philip, Pant, Harish C.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951754/
https://ncbi.nlm.nih.gov/pubmed/17626162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-03-0237
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