Carbon Monoxide Donors or HO-1 Overexpression Block Interleukin-18-Mediated NF-κB-PTEN-Dependent Human Cardiac Endothelial Cell Death

The objective of this study was to determine whether heme oxygenase-1 (HO-1) or heme metabolites exert cytoprotective effects on interleukin-18-mediated endothelial cell (EC) death. Treatment with IL-18 increased NF-κB activation, PTEN induction, suppressed Akt activation, and stimulated EC death. W...

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Main Authors: Zabalgoitia, Miguel, Colston, James T., Reddy, Seenu V., Holt, Jeffrey W., Regan, Raymond F., Stec, David E., Rimoldi, John M., Valente, Anthony J., Chandrasekar, Bysani
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277467/
https://ncbi.nlm.nih.gov/pubmed/18215737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.08.012
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